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A 4 week cycle of DHEA should be suffice to recover testosterone levels, however cycles can be safely extended beyond this point, with DHEA being used for several months in clinical research (8)before the return to higher/normal levels in men.If you are already on DHEA it is important to be aware of its hormonal effect, as it may have a major effect on testosterone clearance in men. While it will not affect sperm motility, it will lead to an increase in luteinising hormone and may significantly reduce the bioavailability of testosterone, and it may not completely affect the bioavailability of testosterone if the concentration of testosterone is kept low enough. In addition to this, it might lead to decreased free testosterone levels, which could result in increased libido in those who also suffer with low testosterone. This will generally be the case in men who consume large quantities of DHEA and testosterone, since there are far fewer estrogen responsive cells in the body.DHEA appears to act primarily by activating the receptor for DHT. So a woman has a much greater testosterone response if a DHEA dose is given every morning, however, this may only be a problem if your DHT levels are very high (or the diet is not very healthy), otherwise DHEA would not provide enough stimulation to increase testosterone levels.The effect of DHT on DHEA is not well understood, as the mechanism might be both similar and slightly different. It may be that other types of norepinephrine release have no influence on DHT, however it may be that stimulation of DHT can be blocked by a hormone called prolactin. These are highly variable and are thought to be due to an interaction with the hormone prolactin receptors in the hypothalamus, which acts at the hypothalamus as a hormone pump. While DHT blocks prolactin receptors by binding to them, prolactin then acts on DHT receptors in a similar fashion to a prolactin receptor antagonist, and this has been shown in a test of D6 and D7 dopamine receptor systems. The only thing this does is stop the receptors from being flooded with prolactin (i.e. to stop it from signalling through prolactin receptors). When this occurs, DHT is not increased (or DHT levels returned to normal), which is why DHT has been shown to inhibit prolactin levels in mice. Also in the same way, we have been shown to need prolactin to stimulate us (8,9).It can also be seen to work through changes in the hypothalamus itself, and this is how it may have effects elsewhere (10). In studies conducted on ratsSimilar articles: